WEB DESK, July 15(ABC): Researchers have designed a simple, low-cost device for subcutaneous injection of viscous formulations.
MIT researchers have developed a simple, low-cost technology to administer powerful drug formulations that are too viscous to be injected using conventional medical syringes.
The technology, which is described in a paper published today in the journal Advanced Healthcare Materials, makes it possible to inject high-concentration drugs and other therapies subcutaneously. It was developed as a solution for highly effective, and extremely concentrated, biopharmaceuticals, or biologics, which typically are diluted and injected intravenously.
“Where drug delivery and biologics are going, injectability is becoming a big bottleneck, preventing formulations that could treat diseases more easily,” says Kripa Varanasi, MIT professor of mechanical engineering. “Drug makers need to focus on what they do best, and formulate drugs, not be stuck by this problem of injectability.”
Leaders at the Bill and Melinda Gates Foundation brought the injectability problem to Varanasi after reading about his previous work on dispensing liquids, which has attracted the attention of industries ranging from aviation to makers of toothpaste. A main concern of the foundation, Varanasi says, was with providing high-concentration vaccines and biologic therapies to people in developing countries who could not travel from remote areas to a medical setting.
In the current pandemic, Varanasi adds, being able to stay home and subcutaneously self-administer medication to treat diseases such as cancer or auto-immune disorders is also important in developed countries such as the United States.
